J3770
JNJ7777120
≥98% (HPLC)
Sinonimo/i:
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine
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About This Item
Formula empirica (notazione di Hill):
C14H16N3OCl
Numero CAS:
Peso molecolare:
277.75
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Colore
white to off-white
Solubilità
DMSO: >20 mg/mL
H2O: insoluble
Ideatore
Johnson & Johnson
Temperatura di conservazione
room temp
Stringa SMILE
CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
InChI
1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
HUQJRYMLJBBEDO-UHFFFAOYSA-N
Applicazioni
JNJ7777120 has been used as a histamine-4 receptor antagonist:
- to study its effects on the pro-inflammatory microglia in rats
- to study its effects on the Parkinson′s-like pathology in rat brain
- to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
Azioni biochim/fisiol
JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
Caratteristiche e vantaggi
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Qiuyuan Fang et al.
Brain, behavior, and immunity, 92, 127-138 (2020-11-30)
Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers and enhanced histamine levels have been observed in the substantia nigra of PD-postmortem brains. Histamine-induced
Susanne Mommert et al.
International archives of allergy and immunology, 166(3), 225-230 (2015-05-01)
Natural killer (NK) cells have been detected in the lesional skin of patients with inflammatory skin diseases, where high levels of histamine are also present. Therefore, we investigated the effect of histamine, in particular via the histamine H4 receptor (H4R)
C Hoffmann et al.
Molecular pharmacology, 88(3), 552-560 (2015-07-15)
Over the past decade the kinetics of ligand binding to a receptor have received increasing interest. The concept of drug-target residence time is becoming an invaluable parameter for drug optimization. It holds great promise for drug development, and its optimization
Heiko Schenk et al.
Immunopharmacology and immunotoxicology, 38(5), 379-384 (2016-08-26)
The modulation of antigen uptake and activation of dendritic cells (DCs) by histamine may function as a regulator of inflammation. Therefore, we sought to determine the impact of histamine on antigen uptake by and activation of murine DCs. DCs from
E Zampeli et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 58(6), 285-291 (2009-02-03)
Although the H(4) receptor localisation in the eye is unresolved, this study aimed to investigate the effects of the H(4) receptor antagonist JNJ7777120 in a model of experimental conjunctivitis. JNJ7777120, at 0.005-1 mmol/l, was instilled into the lower conjunctival fornix
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