C2313
Compound 48/80
powder, hypotensive agent
Sinonimo/i:
Poly-p-methoxyphenethylmethylamine
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About This Item
Codice UNSPSC:
41106300
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Compound 48/80,
Stato
powder
Livello qualitativo
Solubilità
H2O: 50 mg/mL
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Applicazioni
Compound 48/80 has been used:
- to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
- to induce mast cell degranulation
- to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice
Azioni biochim/fisiol
Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.
Nota sulla preparazione
Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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I clienti hanno visto anche
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
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Cellular Signalling, 19(2), 321-329 (2007)
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Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
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