K2628

Ketotifen fumarate salt

≥99% (TLC), powder, H₁ histamine receptor antagonist

• Formula empirica (notazione di Hill): C₁₉H₁₉NOS · C₄H₄O₄
• Numero CAS: 34580-14-8
• Peso molecolare: 425.50
• Numero CE: 252-100-0
• Numero MDL: MFCD00079394
• Codice UNSPSC: 12352200
• ID PubChem: 24278506
• NACRES: NA.77

Proprietà

• Nome del prodotto: Ketotifen fumarate salt,
• Stato: powder
• Livello qualitativo: 100
• Ideatore: Novartis
• Stringa SMILE: OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
• InChI: 1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+; YNQQEYBLVYAWNX-WLHGVMLRSA-N
• Informazioni sul gene: human ... HRH1(3269) , PDE7B(27115)

Descrizione

Descrizione generale

Ketotifen fumarate salt is an antihistamine drug.

Applicazioni

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Azioni biochim/fisiol

H₁ histamine receptor antagonist.

Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves