B3259

Bradykinin

powder, ≥98% (HPLC)

• Formula empirica (notazione di Hill): C₅₀H₇₃N₁₅O₁₁ · xC₂H₄O₂
• Numero CAS: 6846-03-3
• Peso molecolare: 1060.21 (free base basis)
• Numero CE: 227-781-2
• Numero MDL: MFCD00076258
• Codice UNSPSC: 12352106
• NACRES: NA.32

Proprietà

• Grado: for analytical purposes
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white
• Solubilità: 0.1 M acetic acid: 25 mg/mL, clear, colorless
• N° accesso UniProt: P01042
• Temperatura di conservazione: −20°C
• Stringa SMILE: N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1; QXZGBUJJYSLZLT-FDISYFBBSA-N
• Informazioni sul gene: human ... KNG1 (includes EG:3827)

Descrizione

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Applicazioni

Bradykinin acetate salt has been used:

• to stimulate the contraction of guinea pig ileum
• as a contractile agent in fibroblasts
• In the stimulation of endothelium of human subcutaneous artery
• To evoke Ca²⁺ signals in neuroblastoma-glioma hybrid cell line, NG108-15

Azioni biochim/fisiol

Activates pain receptors; induces smooth muscle contraction; activates Ca²⁺-dependent nitric oxide synthetase; increases capillary permeability.

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)