A9650

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

• Sinonimo/i: 5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
• Formula empirica (notazione di Hill): C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
• Numero CAS: 70937-97-2
• Peso molecolare: 1296.48 (anhydrous free base basis)
• Numero MDL: MFCD00133091
• Codice UNSPSC: 12352202
• eCl@ss: 42020611
• ID PubChem: 24891483
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Livello qualitativo: 200
• Saggio: ≥90% (HPLC)
• Forma fisica: powder
• PM: 1296 Da by calculation (Average Mass)
• Condizioni di stoccaggio: (Keep container tightly closed in a dry and well-ventilated place)
• tecniche: cell culture | mammalian: suitable
• Solubilità: acetic acid: 25 mg/mL, clear, colorless
• N° accesso UniProt: P01019
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O
• InChI: 1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1; CKIFOTYDIFUKEP-AUVUXLIHSA-N
• Informazioni sul gene: human ... AGT(183)

Descrizione

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Descrizione generale

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling

Applicazioni

Angiotensin I human acetate salt hydrate has been used:

• as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
• to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
• as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Azioni biochim/fisiol

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.

Preadsorbimento dell’anticorpo

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)