05-23-0101

Angiotensin II, Human

Plays an important role in the regulation of blood pressure.

• Sinonimo/i: Angiotensin II, Human, DRVYIHPF, ang II
• Formula empirica (notazione di Hill): C₅₀H₇₁N₁₃O₁₂
• Numero CAS: 4474-91-3
• Peso molecolare: 1046.18
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Origine biologica: human
• Livello qualitativo: 100
• Sterilità: non-sterile
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• tecniche: cell based assay: suitable
• Colore: white to off-white
• Solubilità: 5% acetic acid: 1 mg/mL; water: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
• InChI: 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1; CZGUSIXMZVURDU-GYGDIBSWSA-N
• Informazioni sul gene: human ... ACE2(59272)

Descrizione

Descrizione generale

Research area: Cell signaling

Cell permeable: no

Primary Target adenylate cyclase activity

Product does not compete with ATP.

Reversible: no

Applicazioni

Angiotensin II, Human has been used to induce fibrosis in mice to evaluate the impact of fibroblast loss on cardiac function after injury. It has also been used to induce abdominal aortic aneurysm (AAA) progression in mice.

Azioni biochim/fisiol

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Furthermore, Angiotensin II stimulates the release of aldosterone from the adrenal gland, contributing to the maintenance of fluid and electrolyte balance regulation. Angiotensin II also promotes inflammation and tissue injury. It Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II also activates JAK2 in smooth muscle cells, as well as several kinases including p125FAK, cytosolic calcium-dependent tyrosine kinase, and p60c-src in various cell types. In vascular smooth muscle cells, it activates ERK1/2, JNK, and p38 MAP Kinase.

Confezionamento

Yes

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Altre note

Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable