C0858
Cyclooxygenase 2 human
≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein
Sinonimo/i:
COX-2, Prostaglandin H synthase 2
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About This Item
Prodotti consigliati
Ricombinante
expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells
Livello qualitativo
Saggio
≥70% (SDS-PAGE)
Stato
aqueous solution
Attività specifica
≥8000 units/mg protein
PM
dimer subunit mol wt 70-74 kDa
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... PTGS2(5743)
Azioni biochim/fisiol
COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is the inducible form of cyclooxygenase, induced by phorbol esters, lipopolysaccharides, and cytokines. COX-2 is upregulated in the neovasculature of malignant tumors. Inhibition of COX-2 with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased tumor growth.
Altre note
Tagged with a six-residue histidine sequence near the N-terminus.
Definizione di unità
One unit will consume 1.0 nanomole of oxygen per minute at pH 8 at 37 °C.
Stato fisico
Solution in 80 mM Tris, pH 8.0, with 0.3 mM DDC, 0.01% TWEEN® 20 and 10% glycerol
Substrati
KM for arachidonate = 6.5 μM. Exhibits activity and sensitivity to NSAIDs similar to the non-tagged enzyme.
Note legali
TWEEN is a registered trademark of Croda International PLC
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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