85558

Spermidine

BioUltra, for molecular biology, ≥99.5% (GC)

• Sinonimo/i: SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Formula condensata: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Numero CAS: 124-20-9
• Peso molecolare: 145.25
• Beilstein: 1698591
• Numero CE: 204-689-0
• Numero MDL: MFCD00008229
• Codice UNSPSC: 12352116
• ID PubChem: 57653053
• NACRES: NA.26

Proprietà

• Grado: Molecular Biology; for molecular biology
• Livello qualitativo: 200
• Nome Commerciale: BioUltra
• Saggio: ≥99.5% (GC)
• Condizioni di stoccaggio: (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
• tecniche: ChIP: suitable; buffer exchange: suitable
• Impurezze: DNases, none detected; RNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected
• Indice di rifrazione: n20/D 1.479 (lit.)
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• Solubilità: H₂O: 1 M at 20 °C, clear, colorless
• Densità: 0.925 g/mL at 25 °C (lit.)
• Anioni in tracce: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• Cationi in tracce: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• Stringa SMILE: NCCCCNCCCN
• Assorbanza UV: λ: 260 nm A_max: 0.1; λ: 280 nm A_max: 0.05
• Compatibilità: suitable for molecular biology
• applicazioni: advanced drug delivery; genomic analysis
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2; ATHGHQPFGPMSJY-UHFFFAOYSA-N
• Informazioni sul gene: rat ... Ppm1a(24666)

Descrizione

Descrizione generale

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Applicazioni

Spermidine has been used:

• as a component of chromosome isolation buffer
• as a component of transcription buffer
• as a component of homogenization buffer

Azioni biochim/fisiol

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

Caratteristiche e vantaggi

• Versatile and adaptable for a wide variety of laboratory and research applications
• Suitable for Molecular Biology and Biochemical research
• Free from DNase, RNase, NICKase, and protease
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
• Tested for trace levels of Anions and Cations

Avvertenza

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Risultati analitici

liquid or solid

Altre note

For additional information on our range of Biochemicals, please complete this form.

In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

Informazioni sulla sicurezza

• Pittogrammi: GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H314
• Consigli di prudenza: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Classi di pericolo: Eye Dam. 1 - Skin Corr. 1B
• Codice della classe di stoccaggio: 8A - Combustible corrosive hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 233.6 °F - closed cup
• Punto d’infiammabilità (°C): 112 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter