5051

Human Vitronectin

from human plasma, liquid, 0.5 mg/mL, suitable for cell culture

• Sinonimo/i: Cell adhesion protein, ECM protein
• Codice UNSPSC: 12352202
• NACRES: NA.75

Proprietà

• Nome del prodotto: Vitronectin, from human plasma, suitable for cell culture, solution
• Origine biologica: human plasma
• Livello qualitativo: 100
• Sterilità: sterile-filtered
• Saggio: >95%
• Stato: solution
• PM: 75 kDa
• Confezionamento: pkg of 0.1 mg
• Concentrazione: 0.5 mg/mL
• tecniche: cell culture | mammalian: suitable
• Solubilità: water: miscible
• N° accesso UniProt: P04004
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... VTN(7448)

Descrizione

Descrizione generale

Vitronectin is a 75 kDa glycoprotein produced by hepatocytes and liberated into the blood. It has four domains and at least two structural motifs. Vitronectin gene is small with three kilobases in length and has eight exons. It is also present on fibers in the extracellular matrices of several tissues.

Vitronectin is a monomeric glycoprotein used to promote cell attachment, migration, proliferation and differentiation in a broad number of cell lines and types. This product has been purified from human plasma where it is found as a mixture of 75kDa and 65kDa polypeptides.

Vitronectin′s primary use in cell culture is related to cell adhesion. It also binds to heparin and collagen.

Vitronectin is ideal for coating of surfaces. The optimal concentration for cell attachment and culture may differ for various cell types. Vitronectin has been used at a final coating concentration as low as 50 ng/cm² on plasticware. It is provided in user-friendly packaging for use and storage. Vitronectin is sterile filtered and is supplied as a ready to use solution after thawing and concentration adjustment.

Azioni biochim/fisiol

Vitronectin controls proteolysis. It helps in in vitro cell adhesion.Vitronectin is involved in the modulation of perforin mediated killing by cytotoxic T-lymphocytes and natural killer (NK) cells. It controls the inflammatory reactions in blood.

Nota sulla preparazione

This product is supplied in a solution of 0.15 M NaCl and 0.005M HEPES at pH 7.4

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable