46985
Fluorescein-5-thiosemicarbazide
suitable for fluorescence, ~80% (HPCE)
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About This Item
Formula empirica (notazione di Hill):
C21H15N3O5S
Numero CAS:
Peso molecolare:
421.43
Numero MDL:
Codice UNSPSC:
12352125
ID PubChem:
NACRES:
NA.32
Prodotti consigliati
Saggio
~80% (HPCE)
Livello qualitativo
Stato
solid
Solubilità
DMF: soluble
H2O: soluble
Fluorescenza
λex 492 nm; λem 516 nm in 0.1 M Tris pH 9.0
Compatibilità
suitable for fluorescence
Temperatura di conservazione
−20°C
Stringa SMILE
NNC(=S)Nc1ccc(c(c1)C(O)=O)C2=C3C=CC(=O)C=C3Oc4cc(O)ccc24
InChI
1S/C21H15N3O5S/c22-24-21(30)23-10-1-4-13(16(7-10)20(27)28)19-14-5-2-11(25)8-17(14)29-18-9-12(26)3-6-15(18)19/h1-9,25H,22H2,(H,27,28)(H2,23,24,30)
MEUCHQDLZYLNQY-UHFFFAOYSA-N
Descrizione generale
Fluorescein-5-thiosemicarbazide, also known as FTC, is a fluorescent probe. The FTSC fluorescent spectra is like FITC, a preferred fluorescent tag for proteomics. The fluorescence spectral properties of FTSC-labeled vesicles obtained by reductive amination are fully compatible with the argon laser of fluorescent instruments.
Applicazioni
Fluorescein-5-thiosemicarbazide can be used as a fluorescent labeling reagent to label:
- Cell-surface functional groups (glycophorins) in the study of the effect of deoxygenation in the red blood cell membrane.
- Saccharides applicable in polysaccharide imaging in live cells.
- Chondroitin sulfate nanogels applicable in cell-specific drug delivery applications.
Caratteristiche e vantaggi
Fluorescein-5-thiosemicarbazide has the following benefits -
- It displays strong fluorescence property.
- Shows an intrinsic reactivity of the thiosemicarbazide group towards the aldehyde group.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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We have used the fluorescence photobleaching recovery technique to study the dependence on oxygen tension of the lateral mobility of fluorescently labeled band 3, the phospholipid analogue fluorescein phosphatidylethanolamine, and glycophorins in normal red blood cell membranes. Band 3 protein
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Oxidative stress and inflammation play important roles in the pathogenesis of cardiovascular disease (CVD). Oxidative stress-induced desialylation is considered to be a primary step in atherogenic modification, and therefore, the attenuation of oxidative stress and/or inflammatory reactions may ameliorate CVD.
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