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31395

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

Mr ~500,000

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About This Item

Numero CAS:
9011-18-1
Numero MDL:
MFCD00081551
Codice UNSPSC:
12352201
NACRES:
NA.21

Origine biologica

(Leuconostoc spp.)

Livello qualitativo

200

Forma fisica

powder

PM

Mr ~500,000

Composizione

Sulfur Content, 16.0-19.0% (dry basis)

Produttore/marchio commerciale

EDQM

Intervallo di pH utile

6.0-8.0 (10 g/L)

Solubilità

H2O: freely soluble 50 mg/mL, clear

Anioni in tracce

chloride (Cl-): ≤100 mg/kg

Cationi in tracce

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤1000 mg/kg
Mg: ≤100 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Temperatura di conservazione

room temp

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Categorie correlate

Applicazioni

Dextran sulfate sodium salt from Leuconostoc sp. was used as a test compound for studying the heparin and dextran sulphate interaction with alkali ions. It was used for releasing DNA from DNA-histone complexes.

Azioni biochim/fisiol

Dextran is a mixture of glucose polymers of varying size and geometry. Dextran in the form of dextran sulfate acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength.The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Nota sulla preparazione

prepared from dextran with Mr ~500,000

Altre note

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Heparin and dextran sulfate antagonize PGI2 inhibition of platelet aggregation.
A Eldor et al.
Thrombosis research, 16(5-6), 617-628 (1979-01-01)
Se Young Choi et al.
Journal of biomedicine & biotechnology, 2010, 943516-943516 (2010-03-20)
A total of 28 male BALB/c mice (average weight 20.7 +/- 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO)
Lisa Nebelin Hvidt et al.
Danish medical journal, 59(11), A4531-A4531 (2012-11-23)
Synthetic colloids are frequently used in fluid resuscitation of septic patients. Despite this, little is known about the potential side effects including the risk of renal failure and bleeding. As practice has changed, we performed a before-and-after study of fluid
Prevention of venous thromboembolism.
G P Clagett et al.
Chest, 108(4 Suppl), 312S-334S (1995-10-01)
Simon Finfer et al.
The New England journal of medicine, 350(22), 2247-2256 (2004-05-28)
It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a
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