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Merck
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Key Documents

14606

Sigma-Aldrich

Colesterolo

tested according to Ph. Eur.

Sinonimo/i:

3β-idrossi-5-colestene, 5-colestene-3β-olo

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About This Item

Formula empirica (notazione di Hill):
C27H46O
Numero CAS:
Peso molecolare:
386.65
Beilstein:
1915888
Numero CE:
Numero MDL:
Codice UNSPSC:
41141804
ID PubChem:
NACRES:
NA.21

agenzia

USP/NF
tested according to Ph. Eur.

Livello qualitativo

Forma fisica

powder

P. eboll.

360 °C (lit.)

Punto di fusione

147-149 °C (lit.)

Solubilità

chloroform: soluble 1 gm in 4.5 ml
diethyl ether: soluble 1 gm in 2.8 ml
pyridine: soluble 1 gm in 1.5 ml
H2O: insoluble
acetone: soluble
alcohol: slightly soluble
alcohol: very soluble (Hot)
benzene: soluble
dioxane: soluble
ethyl acetate: soluble
hexane: soluble
oil: soluble
petroleum ether: soluble

Densità

1.067 g/mL at 25 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
HVYWMOMLDIMFJA-DPAQBDIFSA-N

Informazioni sul gene

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Applicazioni

Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Azioni biochim/fisiol

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.
Componente principale di tutte le membrane biologiche; il colesterolo rappresenta il 25% circa dei lipidi cerebrali totali.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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