MABS193
Anti-v-Src Antibody, clone 327
clone 327, from mouse
Sinonimo/i:
Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
327, monoclonal
Reattività contro le specie
mouse
tecniche
western blot: suitable
Isotipo
IgG1κ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SRC(6714)
Descrizione generale
v-Src is the product of the Rous sarcoma virus (RSV) oncogene, and functions as a non-receptor tyrosine kinase belonging to the family of Src proteins. Srcs are typically activated by dimerized cell surface receptors such as integrins, receptor tyrosine kinases, and cytokine receptors. Activated Src kinases phosphorylate the cytoplasmic domains of these receptors enabling interaction between these receptors and their downstream effector molecules. Src proteins are involved in many cellular processs such as apoptosis, immunity, gene expression, cell adhesion, cell migration, and cell transformation. Previous studies have reported that v-Src plays an important role in tumorigenesis.
Immunogeno
Recombinant protein corresponding to purified pp60src from bacterial recombinants which direct the synthesis of v-Src.
Applicazioni
Anti-v-Src Antibody, clone 327 detects level of v-Src & has been published & validated for use in Western Blotting.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Immunological Signaling
Qualità
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected v-Src in 10 µg of NIH/3T3 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected v-Src in 10 µg of NIH/3T3 cell lysate.
Descrizione del bersaglio
~60 kDa observed
Stato fisico
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Risultati analitici
Control
NIH/3T3 cell lysate
NIH/3T3 cell lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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Gabriella Castoria et al.
PloS one, 8(10), e76899-e76899 (2013-10-17)
Hormones and growth factors influence the proliferation and invasiveness of human mesenchymal tumors. The highly aggressive human fibrosarcoma HT1080 cell line harbors classical androgen receptor (AR) that responds to androgens triggering cell migration in the absence of significant mitogenesis. As
Lilian Varricchio et al.
Molecular cancer research : MCR, 5(11), 1213-1221 (2007-11-21)
This report offers direct evidence that association of the estradiol receptor (ER) with Src triggered by steroid agonists or growth factors controls breast and prostate cancer cell growth. This association is abolished in whole cells and in vitro by a
Dirk Fahrenkamp et al.
Cell communication and signaling : CCS, 13, 10-10 (2015-04-18)
Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5) drives proliferation and survival of leukemic cells and contributes to
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
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