N-075

(±)-N′-Nitrosonornicotine (NNN) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Sinonimo/i: NNN, NNN solution
• Formula empirica (notazione di Hill): C₉H₁₁N₃O
• Numero CAS: 80508-23-2
• Peso molecolare: 177.20
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Forma fisica: liquid
• Caratteristiche: Snap-N-Spike^®/Snap-N-Shoot^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• Concentrazione: 1.0 mg/mL in methanol
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: forensics and toxicology
• Formato: single component solution
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=NN1CCCC1c2cccnc2
• InChI: 1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2; XKABJYQDMJTNGQ-UHFFFAOYSA-N

Descrizione

Descrizione generale

N′-Nitrosonornicotine, also known as NNN, is a nitrosamine and potential carcinogen found in a variety of tobacco products including snuff, cigarettes, chewing tobacco, and cigars. This Certified Spiking Solution^® is suitable for use in nicotine testing or environmental monitoring by LC-MS/MS or GC/MS.

Applicazioni

• Validated Stability Indicating Chromatographic Methods for Quantification of Imidocarb Dipropionate; Application for the Determination of Its Residues in Bovine Meat and Milk Samples.: This study developed and validated chromatographic methods using silica gel 60 F₂₅₄ TLC plates to quantify imidocarb dipropionate residues in bovine meat and milk, highlighting the technique′s stability and reliability in complex matrices (Sedik et al., 2020).


• Development and Validation of Chromatographic Methods for Simultaneous Determination of Paracetamol, Orphenadrine Citrate and Caffeine in Presence of P-aminophenol; Quantification of P-aminophenol Nephrotoxic Impurity Using LC-MS/MS.: This research outlines the development and validation of chromatographic methods on silica gel 60 F₂₅₄ TLC plates for analyzing paracetamol, orphenadrine citrate, and caffeine alongside their nephrotoxic impurities, demonstrating the plate′s effectiveness in simultaneous multi-analyte detection (Boltia et al., 2020).


• Simultaneous Quantification of Chlorpheniramine, Phenylephrine, Guaifenesin in Presence of Preservatives with Detection of Related Substance Guaiacol in their Cough Syrup by RP-HPLC and TLC-Densitometric Methods.: This study developed RP-HPLC and TLC-densitometric methods using silica gel 60 F₂₅₄ TLC plates for the quantification of active ingredients and preservatives in cough syrup, showcasing the plate′s utility in pharmaceutical quality control (Boltia et al., 2019).


• Quantitative Determination of Synthesized Genotoxic Impurities in Nifuroxazide Capsules by Validated Chromatographic Methods.: This work validated chromatographic methods using silica gel 60 F₂₅₄ TLC plates for quantifying genotoxic impurities in nifuroxazide capsules, emphasizing the plate′s precision in detecting trace contaminants (Abdelwahab et al., 2018).


• High-performance Thin-layer Chromatography Method Development, Validation, and Simultaneous Quantification of Four Compounds Identified in Standardized Extracts of Orthosiphon stamineus.: This research presents a validated HPTLC method on silica gel 60 F₂₅₄ TLC plates for simultaneous quantification of compounds in herbal extracts, highlighting the plate′s role in natural product analysis (Hashim et al., 2016).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 51.8 °F - closed cup
• Punto d’infiammabilità (°C): 11.0 °C - closed cup