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Key Documents

Altri documenti

75285

Supelco

N′-Nitrosonornicotine

analytical standard

Sinonimo/i:

1-Nitroso-2-(3-pyridyl)pyrrolidine, 3-(1-Nitroso-2-pyrrolidinyl)pyridine, NNN

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About This Item

Formula empirica (notazione di Hill):
C9H11N3O
Numero CAS:
80508-23-2
Peso molecolare:
177.20
Numero MDL:
MFCD00274581
Codice UNSPSC:
41116107
ID PubChem:
329766318
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Saggio

≥99.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

applicazioni

cleaning products
cosmetics
food and beverages
personal care

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

O=NN1CCCC1c2cccnc2

InChI

1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2
XKABJYQDMJTNGQ-UHFFFAOYSA-N

Categorie correlate

Descrizione generale

N′-Nitrosonornicotine is a tobacco specific nitrosamine, which is found to be carcinogenic in nature. It is produced via nitrosation of nicotine during the process of curing, aging, processing and smoking of tobacco.

Applicazioni

N′-Nitrosonornicotine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled with tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 - H351

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 3 Oral - Carc. 2

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BCCK5634
BCCK1178
BCCG5567
BCCG5217
BCCC9591

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Sigma-Aldrich

N3018

(±)-Nornicotine

USP

USP

1463337

Nicotine Related Compound B

2-(2-Aminoethyl)-1-methylpyrrolidine 97%

Sigma-Aldrich

139505

2-(2-Aminoethyl)-1-methylpyrrolidine

Benzo[a]pyrene-d12 98 atom % D

Sigma-Aldrich

451797

Benzo[a]pyrene-d12

Supelco

Supelco

47537-U

52 Component Indoor Air Standard

Benzene-d6 "100%", 99.96 atom % D

Sigma-Aldrich

175870

Benzene-d6

(−)-Nicotine ≥99% (GC), liquid

Sigma-Aldrich

N3876

(−)-Nicotine

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes
Patten JC, et al.
Carcinogenesis, 18(8), 1623-1630 (1997)
Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine
Kavvadias D, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 877(11-12), 1185-1192 (2009)
Sultana Shahana Banu et al.
International journal for parasitology, 49(7), 555-567 (2019-05-21)
In the Indian subcontinent, infection with Leishmania donovani can cause fatal visceral leishmaniasis. Genetic variation in L. donovani is believed to occur rapidly from environmental changes and through selective drug pressures, thereby allowing continued disease occurrence in this region. All
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Frontiers in microbiology, 8, 2063-2063 (2017-11-09)
Corals that naturally thrive under extreme conditions are gaining increasing attention due to their importance as living models to understand the impact of global warming on world corals. Here, we present the first metagenomic study of viral communities in corals
Julia Heger-Stevic et al.
PLoS pathogens, 14(12), e1007488-e1007488 (2018-12-20)
Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA
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