830843P

10:0 PA

1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt), powder

• Sinonimo/i: PA(10:0/10:0)
• Formula empirica (notazione di Hill): C₂₃H₄₄O₈PNa
• Numero CAS: 321883-64-1
• Peso molecolare: 502.55
• Numero MDL: MFCD03788002
• Codice UNSPSC: 51191904
• NACRES: NA.25

Proprietà

• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 25 mg (830843P-25mg); pkg of 1 × 500 mg (830843P-500mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand 830843P
• Tipo di lipide: cardiolipins; phospholipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@@](COP([O-])(O)=O)(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O.[Na+]
• InChI: 1S/C23H45O8P.Na/c1-3-5-7-9-11-13-15-17-22(24)29-19-21(20-30-32(26,27)28)31-23(25)18-16-14-12-10-8-6-4-2;/h21H,3-20H2,1-2H3,(H2,26,27,28);/q;+1/p-1/t21-;/m1./s1; YVHWEENUNNUSBE-ZMBIFBSDSA-M

Descrizione

Descrizione generale

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

Applicazioni

10:0 PA may be used:

• as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission
• to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to activate protein kinase C (PKC)
• as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

Azioni biochim/fisiol

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

Confezionamento

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)

5 mL Clear Glass Sealed Ampule (830843P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids