Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

407593

Sigma-Aldrich

Methyl 4-bromobenzoate

99%

Sinonimo/i:

1-Bromo-4-(methoxycarbonyl)benzene, 4-Bromobenzoic acid methyl ester, 4-Methoxycarbonyl-1-bromobenzene, 4-Methoxycarbonylphenyl bromide, Methyl p-bromobenzoate, p-Bromobenzoic acid methyl ester

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula condensata:
BrC6H4CO2CH3
Numero CAS:
619-42-1
Peso molecolare:
215.04
Beilstein:
2045132
Numero CE:
210-596-6
Numero MDL:
MFCD00013531
Codice UNSPSC:
12352100
ID PubChem:
24865465
NACRES:
NA.22

Livello qualitativo

100

Saggio

99%

Forma fisica

powder

Punto di fusione

77-81 °C (lit.)

Gruppo funzionale

bromo
ester

Stringa SMILE

COC(=O)c1ccc(Br)cc1

InChI

1S/C8H7BrO2/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5H,1H3
CZNGTXVOZOWWKM-UHFFFAOYSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Categorie correlate

Descrizione generale

Methyl 4-bromobenzoate is a para-substituted aryl bromide. Mol­ecules of methyl 4-bromobenzoate are almost planar. The compound is isostructural with methyl 4-iodo­benzoate. The Zeeman effect on the N.Q.R. (nuclear quadrupole resonance) of methyl 4-bromobenzoate on single crystals, has been investigated by the ′geometric method′.

Applicazioni

Methyl 4-bromobenzoate may be used in the following syntheses:
  • Three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogs, employed as antifolates.
  • Methyl 4-tri-n-butylstannylbenzoate.
  • Methyl 4-(2-pyridyl)benzoate by cross coupling reaction with lithium 2-pyridyltriolborate.
  • Methyl 4-imidazo[1,2-a]pyridin-3-ylbenzoate by ligand-free Pd(OAc)2 catalyzed reaction with Imidazo[1,2-a]pyridine.
  • Methyl (E)-4-[3-(2-methoxycarbonylvinyl)-thiophen-2-yl]acrylate by reacting with methyl (E)-3-(thiophen-3-y)lacrylate.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
MKCB7016
MKBL2873V
MKBC9481V
MKBC9481
MKAA0933

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 4

1 of 4

Methyl p-toluate ≥99%

Sigma-Aldrich

259667

Methyl p-toluate

4′-Bromoacetophenone 98%

Sigma-Aldrich

B56404

4′-Bromoacetophenone

Methyl 3-(bromomethyl)benzoate 97%

Sigma-Aldrich

648116

Methyl 3-(bromomethyl)benzoate

Methyl 3,5-dinitrobenzoate 99%

Sigma-Aldrich

386367

Methyl 3,5-dinitrobenzoate

Methyl 4-bromobenzoate.
Bolte M and Wissler J.
Acta Crystallographica Section E, Structure Reports Online, 62(3), o1192-o1193 (2006)
Palladium-acetate catalyst for regioselective direct arylation at C2 of 3-furanyl or 3-thiophenyl acrylates with inhibition of Heck type reaction.
Chen L, et al.
Tetrahedron, 69(22), 4381-4388 (2013)
Phosphine-free palladium-catalyzed direct arylation of imidazo [1,2-a] pyridines with aryl bromides at low catalyst loading.
Fu HY, et al.
The Journal of Organic Chemistry, 77(9), 4473-4478 (2012)
Aleem Gangjee et al.
Journal of medicinal chemistry, 47(27), 6893-6901 (2004-12-24)
Bridge homologation of the previously reported classical two-carbon-bridged antifolates, a 5-substituted 2,4-diaminofuro[2,3-d]pyrimidine (1) [which is a 6-regioisomer of LY231514 (Alimta)] and a 6-subsituted 2-amino-4-oxopyrrolo[2,3-d]pyrimidine, afforded the three-carbon-bridged antifolates analogues 4 and 5, with enhanced inhibitory activity against tumor cells in
Zeeman effect on the nuclear quadrupole resonance of 81Br in single crystals of methyl 4-bromobenzoate, 4, 4'-dibromodiphenyl-ether and 4, 4'-dibromodiphenylsulphide at 77 K.
Ambrosetti R, et al.
Molecular Physics, 28(2), 551-558 (1974)
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.