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359351

Sigma-Aldrich

3-Isochromanone

98%

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About This Item

Formula empirica (notazione di Hill):
C9H8O2
Numero CAS:
4385-35-7
Peso molecolare:
148.16
Beilstein:
123692
Numero CE:
224-493-9
Numero MDL:
MFCD00043005
Codice UNSPSC:
12352100
ID PubChem:
24862071
NACRES:
NA.22

Saggio

98%

Punto di fusione

80-82 °C (lit.)

Gruppo funzionale

ester

Stringa SMILE

O=C1Cc2ccccc2CO1

InChI

1S/C9H8O2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
ILHLUZUMRJQEAH-UHFFFAOYSA-N

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Descrizione generale

3-Isochromanone has been reported to be isolated from the fungus Nigrospora sp. PSU-F12. An improved Knoevenagel condensation of 3-isochromanone with aromatic aldehydes has been achieved by microwave irradiation on solid supports in the presence of various catalysts. Synthesis of 3-isochromanone via Beayer-Villiger rearrangement has been reported.

Applicazioni

3-Isochromanone may be used as starting reagent in the synthesis of of BDPBI (7-bromo-1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)2H-isoquinolin-3-one dihydrochloride).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKBB4403
19529KR
11821DU
11325AA
11212BU

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András Vass et al.
Journal of biochemical and biophysical methods, 69(1-2), 179-187 (2006-05-09)
An improved Knoevenagel condensation of 3-isochromanone and aromatic aldehydes can be achieved by microwave irradiation on solid supports in the presence of various catalysts. This synthetic method offers some major advantages, especially the possibility to change the ratio of E/Z
Vatcharin Rukachaisirikul et al.
Archives of pharmacal research, 33(3), 375-380 (2010-04-03)
Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (-)-drimenin (7) and diketopiperazine derivative
3-Isochromanone.
Markgrar JH and Basta SJ.
Synthetic Communications, 2(3), 139-141 (1972)
Chia Hsien Lin et al.
Pharmacology, 67(4), 202-210 (2003-02-22)
The pharmacological effects of BDPBI (7-bromo-1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)2H-isoquinolin-3-one dihydrochloride) were tested on isolated endothelium-containing or denuded aorta of the guinea pig. BDPBI with the formula C(27)H(24)BrCl(2)N(3)O was synthesized starting with 3-isochromanone. In the endothelium-containing preparations of the aortic rings, phenylephrine (PHE; 10

Articoli

Knoevenagel Condensation Reaction

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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