G6793

GW7647

≥98% (HPLC)

• Synonym(e): 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)­phenyl­thio)-2-methyl­propionic acid
• Empirische Formel (Hill-System): C₂₉H₄₆N₂O₃S
• CAS-Nummer: 265129-71-3
• Molekulargewicht: 502.75
• MDL-Nummer: MFCD06798379
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278790
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Farbe: white
• Löslichkeit: DMSO: soluble 16 mg/mL; H₂O: insoluble
• SMILES String: CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
• InChI: 1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
• InChIKey: PKNYXWMTHFMHKD-UHFFFAOYSA-N
• Angaben zum Gen: human ... PPARA(5465)

Beschreibung

Anwendung

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

• in defatting medium to treat primary human hepatocytes
• to test its effect on the glycolytic function in cardiomyocytes
• to test its effect on infant mouse heart
• in breast cancer MDA-MB-231 cells to activate PPARs

Biochem./physiol. Wirkung

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.

Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Rechtliche Hinweise

Sold for research purposes only under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)