1372050

Lysophosphatidylcholine

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): L-α-Lysophosphatidylcholine from egg yolk, 1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
• Número CAS: 9008-30-4
• Número MDL: MFCD00131444
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: lysophosphatidylcholine
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Lysophosphatidylcholine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Egg Phospholipids

Ações bioquímicas/fisiológicas

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na⁺ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K⁺ channels.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable