1297001

Gonadotrofina coriônica

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): Coriogonina, HCG
• Número CAS: 9002-61-3
• Número MDL: MFCD00130797
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: gonadotropin
• peso molecular: 37.9 kDa
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

O hormônio da glicoproteína consiste de uma cadeia α de 92 aminoácidos idêntica à do LH, FSH e TSH; e uma cadeia β distinta de 149 aminoácidos. Produzido por tecido coriônico e responsável pela manutenção do corpo lúteo durante o início da gravidez. Também produzido por neoplasias trofoblásticas, que são caracterizadas por elevado número de cadeias β de hCG livres e hCG hiperglicosilado.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

• Comprehensive Prenatal Screening: Human chorionic gonadotropin (hCG) is crucial in combined first-trimester screening and invasive diagnostics for chromosomal aberrations, offering insights into prenatal health and improving detection rates compared with non-invasive prenatal testing (NIPT). This underscores hCG′s vital role in early gestational health assessments (Gadsbøll et al., 2024).


• Twin Pregnancy Outcomes: hCG levels are studied for their association with adverse outcomes in twin gestations, providing valuable data for managing and monitoring high-risk pregnancies. This research highlights hCG′s predictive value in obstetrics, aiding in the anticipatory management of potential complications (Yamasato and Ono, 2024).


• Missed Abortion Treatment: The effectiveness of Nigella sativa oil, influenced by hCG levels, on the outcomes of missed abortions is explored through a randomized clinical trial. This study demonstrates the potential for integrating hCG monitoring into therapeutic strategies to improve pregnancy outcomes (Mohammadi et al., 2024).


• Germ Cell Testicular Tumor Biomarkers: The role of hCG as a biomarker in germ cell testicular tumors is examined, enhancing the understanding of tumor biology and improving diagnostic accuracy. This research is pivotal for developing targeted therapies and improving prognostic evaluations in oncology (Kılınç et al., 2024).


• Molar Cesarean Scar Ectopic Pregnancy: Studies involving hCG focus on its implications in rare cases of molar cesarean scar ectopic pregnancies, providing insights into unusual gestational complications. This research is crucial for developing guidelines and treatment protocols in exceptionally complex pregnancy cases (Hosseinimousa et al., 2024).

Embalagem

1 vial, 530 USP units per package

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

This product is part of the USP Biologics program.

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Warning
• Frases de perigo: H361
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable