Y0002055

Fingolimod hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Sinônimo(s): FTY720, 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride
• Fórmula empírica (Notação de Hill): C₁₉H₃₃NO₂ · HCl
• Número CAS: 162359-56-0
• Peso molecular: 343.93
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• fonte biológica: synthetic
• grau: pharmaceutical primary standard
• Agency: EP
• família API: fingolimod
• forma: powder
• embalagem: pkg of 110 mg
• fabricante/nome comercial: EDQM
• condição de armazenamento: protect from light
• solubilidade: water: 100-1000 g/L
• aplicação(ões): pharmaceutical
• formato: neat
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
• chave InChI: SWZTYAVBMYWFGS-UHFFFAOYSA-N

Descrição

Descrição geral

Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Warning
• Frases de perigo: H373
• Declarações de precaução: P260 - P314 - P501
• Classificações de perigo: STOT RE 2
• Órgãos-alvo: Immune system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable