Z4777

ZK 200775 hydrate

≥98% (HPLC), powder

• Sinônimo(s): Fanapanel, MPQX, [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate
• Fórmula empírica (Notação de Hill): C₁₄H₁₅F₃N₃O₆P · xH₂O
• Número CAS: 1255517-78-2
• Peso molecular: 409.25 (anhydrous basis)
• Número MDL: MFCD18452859
• Código UNSPSC: 12352200
• ID de substância PubChem: 329831618
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: off-white to light brown
• solubilidade: DMSO: ≥20 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.OP(O)(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)N3CCOCC3)C(F)(F)F
• InChI: 1S/C14H15F3N3O6P.H2O/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9;/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25);1H2
• chave InChI: RYQLMFHPDNKPKY-UHFFFAOYSA-N

Descrição

Descrição geral

Z 200775 is a competetive AMPA/kainate receptor antagonist.

ZK 200775 is a selective AMPA/kainite receptor antagonist with very low affinity for NMDA associated binding sites (Ki for CNQX binding site = 32 nM vs. 2.8 uM for DCKA binding site.) ZK 200775 displays superior PK and safety profiles in in vivo studies compared to quinoxalinedione antagonists such as NBQX, showing no effects on motor behavior or cardiac events at efficacious doses in rat. Additionally, unlike other quinoxalinediones, ZK 200775 is water soluble, making this a desirable tool compound for in vivo studies.

Características e benefícios

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable