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X3629

Sigma-Aldrich

X80

≥98% (HPLC)

Sinônimo(s):

5-(5-{[1-(3-carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}-2-furyl)-2-chlorobenzoic acid

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About This Item

Fórmula empírica (Notação de Hill):
C23H15ClN2O6
Número CAS:
292065-64-6
Peso molecular:
450.83
Número MDL:
MFCD02086439
Código UNSPSC:
12352200
ID de substância PubChem:
329830804
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

cor

orange

solubilidade

DMSO: >40 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC1=NN(c2cccc(c2)C(O)=O)C(=O)\C1=C/c3ccc(o3)-c4ccc(Cl)c(c4)C(O)=O

InChI

1S/C23H15ClN2O6/c1-12-17(21(27)26(25-12)15-4-2-3-14(9-15)22(28)29)11-16-6-8-20(32-16)13-5-7-19(24)18(10-13)23(30)31/h2-11H,1H3,(H,28,29)(H,30,31)/b17-11-

chave InChI

XZRBYOCWWJMJRZ-BOPFTXTBSA-N

Aplicação

X80 has been used as an inhibitor of nucleotide excision repair (NER) pathway to study its effects on 8-hydroxy-2′-deoxyguanosine (8-OHdG) excision in the zygote post-fertilization.

Ações bioquímicas/fisiológicas

X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H413

Declarações de precaução

P273 - P301 + P312 + P330

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 4

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Suicide officially kills approximately 30,000 annually in the United States. Analysis of this leading public health problem is complicated by undercounting. Despite persisting socioeconomic and health disparities, non-Hispanic Blacks and Hispanics register suicide rates less than half that of non-Hispanic
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Journal of agricultural and food chemistry, 67(4), 1261-1268 (2019-01-10)
Many organisms possess the ability to produce metal-binding proteins to absorb cadmium. Metallothioneins, an important family of cysteine-rich metal-binding proteins, have been isolated and well characterized. However, Lentinula edodes may have a different type of cadmium-binding protein that contains fewer
Fertilization stimulates 8-hydroxy-2?-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo
Lord T and Aitken RJ
Developmental Biology, 406(1), 1-13 (2015)
Wendy G Cárdenas-Coronel et al.
Journal of agricultural and food chemistry, 64(1), 302-309 (2015-12-03)
Quality and compositional changes were determined in noni fruit harvested at five ripening stages, from dark-green to thaslucent-grayish. Fruit ripening was accompanied by acidity and soluble solids accumulation but pH diminution, whereas the softening profile presented three differential steps named
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