V5765
Vascular Endothelial Growth Factor 165 human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Sinônimo(s):
Vascular Endothelial Growth Factor 165
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.77
Produtos recomendados
Nome do produto
VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture
fonte biológica
human
Nível de qualidade
recombinante
expressed in HEK 293 cells
descrição
Vascular Endothelial Growth Factor 165 human
Ensaio
≥95% (SDS-PAGE)
Formulário
lyophilized powder
potência
<10 ng/mL ED50
qualidade
endotoxin tested
peso molecular
dimer 42 kDa (glycosylated)
embalagem
pkg of 10 μg
pkg of 50 μg
técnica(s)
cell culture | mammalian: suitable
Impurezas
<0.075 EU/μg
cor
white
solubilidade
water: soluble
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... VEGFA(7422)
Categorias relacionadas
Descrição geral
VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Ações bioquímicas/fisiológicas
VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
Nota de análise
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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A O Afuwape et al.
Histology and histopathology, 17(3), 961-972 (2002-08-10)
The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement
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Cancer letters, 332(1), 3-10 (2013-01-26)
Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis. VEGF is a promising target for therapeutic intervention in
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