Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

U6508

Sigma-Aldrich

UCN-01

≥97% (HPLC), powder

Sinônimo(s):

KW-2401

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C28H26N4O4
Número CAS:
112953-11-4
Peso molecular:
482.53
Número MDL:
MFCD26960886
Código UNSPSC:
12352200
ID de substância PubChem:
24724639
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥97% (HPLC)

Formulário

powder

atividade óptica

[α]20/D 130 to 160°, c = 0.2 in DMSO

condição de armazenamento

protect from light

cor

light yellow

solubilidade

DMSO: >5 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1

chave InChI

PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Informações sobre genes

human ... CDK2(1017) , CDK4(1019) , CDK6(1021) , CHEK1(1111) , PDPK1(5170) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584) , PRKCQ(5588) , PRKCZ(5590) , PRKD1(5587) , PRKD3(23683)

Categorias relacionadas

Aplicação

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Ações bioquímicas/fisiológicas

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Características e benefícios

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
112M4619V
052M4619V
091M4612V
110M4603V
058K46112

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 4

1 of 4

CEP-701 hydrate ≥98% (HPLC)

Sigma-Aldrich

C7869

CEP-701 hydrate

GF 109203X synthetic, ≥90% (HPLC)

Sigma-Aldrich

G2911

GF 109203X

Enzastaurin ≥98% (HPLC)

Sigma-Aldrich

SML0762

Enzastaurin

7-Oxostaurosporine ≥98% (HPLC)

Sigma-Aldrich

SML0984

7-Oxostaurosporine

Motofumi Suzuki et al.
Translational oncology, 10(4), 491-500 (2017-05-28)
Checkpoint kinase 1 (Chk1) is an evolutionarily conserved serine/threonine kinase that plays an important role in G
Sung-Bau Lee et al.
Science advances, 4(8), eaat4985-eaat4985 (2018-08-14)
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1
Tiara Bunga Mayang Permata et al.
Oncogene, 38(23), 4452-4466 (2019-02-14)
Programmed death-ligand 1 (PD-L1) is a key factor influencing cancer immunotherapy; however, the regulation of PD-L1 expression in cancer cells remains unclear, particularly regarding DNA damage, repair and its signalling. Herein, we demonstrate that oxidative DNA damage induced by exogenously
Sacha Benaoudia et al.
EMBO reports, 20(9), e48235-e48235 (2019-07-30)
Caspase-4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non-canonical inflammasome, which drives inflammatory responses during Gram-negative bacterial infections. It remains unclear whether other proteins regulate cytosolic LPS sensing, particularly in human cells. Here, we conduct
S Akinaga et al.
Anti-cancer drug design, 15(1), 43-52 (2000-07-11)
UCN-01 (7-hydroxystaurosporine) is a protein kinase inhibitor which is under development as an anti-cancer agent in the USA and Japan. Although UCN-01 was originally isolated from the culture broth of Streptomyces sp. as a protein kinase C-selective inhibitor, its ultimate
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica