U3385

UA62784

≥98% (HPLC)

• Sinônimo(s): 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
• Fórmula empírica (Notação de Hill): C₂₃H₁₅NO₃
• Número CAS: 313367-92-9
• Peso molecular: 353.37
• Número MDL: MFCD00489199
• Código UNSPSC: 12352202
• ID de substância PubChem: 329827627
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: yellow
• solubilidade: DMSO: >2 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
• InChI: 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• chave InChI: SVICLWPFAQYZLX-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Nota de preparo

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable