T6448
Anti-TREK-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-Kcnk2, Anti-Potassium Channel K2P2.1, Anti-TWIK-related K+ channel 1
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
rat
técnica(s)
western blot (chemiluminescent): 1:200 using rat brain membranes
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... KCNK2(3776)
rat ... Kcnk2(170899)
Descrição geral
Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family.
Especificidade
The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18).
Imunogênio
synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28).
Aplicação
Anti-TREK-1 antibody produced in rabbit has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Ações bioquímicas/fisiológicas
Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia.
forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Analysis of gene expression profiles in the programmed cell death rat retinal ganglion cells (RGC-5).
Abdelnaby K, et al.
Cancer Therapy, 6(2) (2008)
Naaz Andharia et al.
Channels (Austin, Tex.), 11(3), 224-235 (2017-01-14)
The TREK-1 channel, the TWIK-1-related potassium (K
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats
Chunlin C, et al.
Acta Pharmaceutica Sinica. B, 5(1), 55-61 (2015)
Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction
Junlong Z,et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 1064-1064 (2018)
Chunlin Chen et al.
Acta pharmaceutica Sinica. B, 5(1), 55-61 (2015-11-19)
The purpose of this study is to investigate the expression of major potassium channel subtypes in the brain of chronical mild stress (CMS) rats and reveal the effects of fluoxetine on the expression of these channels. Rats were exposed to
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