T5391
apo-Transferrina
γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98%
Sinônimo(s):
Siderofilina, Transferrina humana
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About This Item
Produtos recomendados
Nível de qualidade
esterilidade
γ-irradiated
linha de produto
BioXtra
Ensaio
≥98%
Formulário
powder
peso molecular
76-81 kDa
concentração
~25 mM
técnica(s)
cell culture | mammalian: suitable
Impurezas
HIV and HBsAg, source material tested negative
iron, essentially free
solubilidade
H2O: 50 mg/mL
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TF(7018)
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Descrição geral
apo-Transferrin (aTF) human can be supplemented with iron or used to bind free iron present in media. It can be used to transport iron into mammalian cells.
Aplicação
apo-Transferrin human has been used as a supplement:
- in Dulbecco′s modified Eagle medium/HamF12 (DMEM/F-12) to culture human adrenocortical carcinoma cells
- in DMEM/F-12 to culture neural precursor cells from mice
- in collecting medium NCSU23 to culture preantral follicles from porcine ovaries
Ações bioquímicas/fisiológicas
apo-Transferrin (aTF) is an endogenous iron chelator and shows protective effects in the host by scavenging free iron and preventing the formation of toxic reactive oxygen species (ROS). It shows a therapeutic effect against thalassemia. After the release of iron, receptor-bound apo-transferrin reaches the cell surface instead of being transported to lysosomes for degradation. The cell surface has a neutral pH that promotes the release of apo-transferrin from its receptor, where it can again circulate and bind additional iron to undergo further rounds of iron delivery to cells.
Outras notas
Proteína transportadora de ferro não heme.
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
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