T2752

3,3′,5-Triiodo-L-thyronine sodium salt

≥95% (HPLC)

• Sinônimo(s): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Fórmula empírica (Notação de Hill): C₁₅H₁₁I₃NNaO₄
• Número CAS: 55-06-1
• Peso molecular: 672.96
• Beilstein: 8179867
• Número CE: 200-223-5
• Número MDL: MFCD00002594
• Código UNSPSC: 51111800
• ID de substância PubChem: 24900071
• NACRES: NA.32

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Ensaio: ≥95% (HPLC)
• forma: powder
• técnica(s): cell culture | mammalian: suitable
• solubilidade: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• chave InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Informações sobre genes: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Descrição

Aplicação

3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells. The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.

Ações bioquímicas/fisiológicas

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.

Nota de preparo

3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)