SRP5066
PIM1, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
PIM
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
recombinante
expressed in baculovirus infected Sf9 cells
linha de produto
PRECISIO® Kinase
Ensaio
≥70% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
atividade específica
269-363 nmol/min·mg
peso molecular
~62 kDa
nº de adesão NCBI
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... PIM1(5292)
Descrição geral
PIM1 is a proto-oncogene that belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, PIM1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of PIM1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Expression of PIM1 is mediated through activation of the JAK/STAT pathway.
forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparo
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Informações legais
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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M Friedmann et al.
Archives of biochemistry and biophysics, 298(2), 594-601 (1992-11-01)
The human pim-1 proto-oncogene was expressed in Escherichia coli as a glutathione-S-transferase (GST)-fusion protein and the enzymatic properties of its kinase activity were characterized. Likewise, a Pim-1 mutant lacking intrinsic kinase activity was constructed by site-directed mutagenesis (Lys67 to Met)
T C Meeker et al.
Journal of cellular biochemistry, 35(2), 105-112 (1987-10-01)
The mouse PIM-1 gene has been implicated in the evolution of retrovirus-associated mouse lymphomas. We have initiated a study of the human PIM-1 gene because of its potential importance as a human oncogene. We have isolated genomic and cDNA clones
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