SRP5009
CDK1/CyclinB1, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
CCNB, CCNB1, CDC2
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
recombinante
expressed in baculovirus infected Sf9 cells
linha de produto
PRECISIO® Kinase
Ensaio
≥70% (SDS-PAGE)
forma
buffered aqueous glycerol solution
atividade específica
12-16 nmol/min·mg
peso molecular
~58 kDa (CDK1)
~75 kDa (CyclinB1)
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... CCNB1(891) , CDK1(983)
Descrição geral
The cyclin B1 (CCNB1) gene is mapped to human chromosome 5q13.2. The gene codes for a 62kDa protein containing a classical cyclin box domain. CCNB1 shuttles between the nucleus and cytoplasm until prophase begins. It is a member of the cyclin family and is expressed at low levels in normal cells. CDK1 (cyclin-dependent kinase 1) belongs to the Ser/Thr protein kinase family. The gene encoding it is localized on human chromosome 10q21.
Ações bioquímicas/fisiológicas
The cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1) complex plays a crucial role in the regulation of mitosis. Elevated expression of CCNB1 has been observed in various types of human cancers including breast, lung, colon, prostate and head and neck cancers. Thus, this protein can be considered as a potent target for cancer vaccines.In addition, CCNB1 also serves as a prognostic biomarker for estrogen-receptor-positive (ER+) breast cancer. CDK1 (cyclin-dependent kinase 1) controls various mitotic processes like reorganization of the cytoskeleton and segregation of chromosomes. It is essential for the multiplication of mammalian cells.
forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparo
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Informações legais
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer
Yifeng Yang
Cancer Biology & Therapy (2014)
The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors
Claire Chevaleyre
Journal of Immunology, 195(4) (2015)
CCNB1 is a prognostic biomarker for ER+ breast cancer
Kun Ding
Medical Hypotheses, 83(3) (2014)
Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
Ivan B
Molecular Cancer (2011)
Soraya Játiva et al.
Cellular and molecular life sciences : CMLS, 76(18), 3601-3620 (2019-03-31)
Exit from mitosis and completion of cytokinesis require the inactivation of mitotic cyclin-dependent kinase (Cdk) activity. In budding yeast, Cdc14 phosphatase is a key mitotic regulator that is activated in anaphase to counteract Cdk activity. In metaphase, Cdc14 is kept
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