SRP4137

IL-4 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Sinônimo(s): B cell stimulating factor, BCDF, BCGF, BSF-1, IL-4, Lymphocyte stimulatory factor 1
• Número MDL: MFCD00151705
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥98% (HPLC); ≥98% (SDS-PAGE)
• Formulário: lyophilized
• peso molecular: ~15.0 kDa
• embalagem: pkg of 10 μg
• Impurezas: endotoxin, tested
• nº de adesão NCBI: P05112
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... IL4(3565)

Descrição

Descrição geral

The gene IL-4 (interleukin 4) is mapped to human chromosome 5q31.1. Human IL-4 is a 15kDa globular protein containing 130 amino acid residues. It is a cytokine which is mainly secreted by activated Th2 (T helper) cells.

Aplicação

IL-4 (interleukin 4) has been used to polarize the human monocytic leukemia (THP-1) cells to M2-like phenotype.

In inflamed porcine endometrium, IL-4 (interleukin 4)-human has been used to study effects of IL-4 on the leukotriene B4 and leukotriene C4 synthesis as well as secretion. It has been used to study the effect of IL-4 on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.

Ações bioquímicas/fisiológicas

IL-4 (Interleukin 4) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It exhibits anti-inflammatory responses and participates in immune processes by providing protection from intracellular pathogens. IL-4 also plays an important role in Th2 (T helper cells) differentiation. Additionally, it can suppress pro-inflammatory cytokines. IL-4 is associated with pemphigus. Also, mutation in the gene is linked with risk of dental implant loss. In children, IL-4 might be involved with risk of asthma and Mycoplasma pneumoniae infection.

forma física

Sterile filtered and lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable