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Key Documents

SRP3252

Sigma-Aldrich

SDF-1 alpha from rat

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sinônimo(s):

CXCL12, PBSF, Stromal-Cell Derived Factor-1

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

rat

recombinante

expressed in E. coli

Ensaio

≥98% (HPLC)
≥98% (SDS-PAGE)

forma

lyophilized

potência

50.0-100.0 ng/mL

peso molecular

7.9 kDa

embalagem

pkg of 10 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white

nº de adesão UniProt

Q9QZD1

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

rat ... CXCL12(24772)

Categorias relacionadas

Descrição geral

Stromal cell-derived factor 1 α and β (SDF-1α and β) are stromal derived CXC chemokines, and signal through the C-X-C motif chemokine receptor-4 (CXCR4). SDF-1α is also known as C-X-C motif chemokine ligand 12 (CXCL12). Recombinant rat SDF-1α is a 7.9kDa protein containing 68 amino acid residues.

Aplicação

Stromal cell-derived factor 1 α (SDF-1α ) has been used in cell migration assay and fibrin gel bead assay.

Ações bioquímicas/fisiológicas

Stromal cell-derived factor 1 α and β (SDF-1α and β) chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. SDF-1 α modulates leukocyte and hematopoietic precursor migration and pre-B cell proliferation.

Sequência

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.
Papangeli I
Nature Communications, 7, 11268-11268 (2016)
Stromal cell-derived factor 1a (SDF-1a): A marker of disease burden in patients with atrial fibrillation.
Li D
Scandinavian Cardiovascular Journal : SCJ, 50(1), 35-41 (2016)
Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.
Tanaka T
The American Journal of Pathology, 156(6), 2149-2157 (2000)
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul CC
The Journal of Experimental Medicine, 184(3), 1101-1109 (1996)
A Aiuti et al.
The Journal of experimental medicine, 185(1), 111-120 (1997-01-06)
Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stromal cells. This is the first chemoattractant reported for human CD34+ progenitor cells. Concentrations of SDF-1 that elicit
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