SRP0115
Sirtuin 1 human
recombinant, expressed in E. coli, ≥60% (SDS-PAGE)
Sinônimo(s):
SIR2, SIRT1, Sir2A, sir2-like 1
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥60% (SDS-PAGE)
forma
aqueous solution
peso molecular
87.2 kDa
embalagem
pkg of 100 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... SIRT1(23411)
Descrição geral
Human Sirtuin 1, GenBank Accession No. NM_012238), amino acids 193-741 with N-terminal ST tag, MW = 87.2 kDa, expressed in E. coli expression system.
Aplicação
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Definição da unidade
One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.
forma física
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
Nota de preparo
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells.
Li S, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 1593-1600 (2016)
[SIRT1].
Hattori Y and Ihara M.
Nihon Rinsho. Japanese Journal of Clinical Medicine, 74(4), 589-594 (2016)
Wen-Li Mu et al.
Stem cells (Dayton, Ohio), 33(7), 2135-2147 (2015-05-06)
Mouse somatic cells can be reprogrammed into induced pluripotent stem cells by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. Together with Oct4, Sox2 plays a major role as a master endogenous pluripotent genes trigger in
Yanxiang Li et al.
The Journal of nutritional biochemistry, 26(11), 1338-1347 (2015-08-25)
Nicotinic acid (NA) has recently been shown to inhibit inflammatory response in cardiovascular disease. Sirtuin1 (SIRT1), a NAD(+)-dependent class III histone deacetylase, participates in the regulation of cellular inflammation. We hypothesized that dietary supplementation of NA could attenuate vascular inflammation
Yun H Kim et al.
Vascular pharmacology, 72, 35-42 (2015-05-15)
Silent mating type information regulation 2 homolog 1 (SIRT1) is known as a key regulator in the protection of various vascular disorders, however, no direct evidences have been reported in the progression of atherosclerosis. Considering the pivotal role of matrix
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