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Documentos Principais

SML3192

Sigma-Aldrich

GLX481304

≥98% (HPLC)

Sinônimo(s):

2-N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1,3,5-triazine-2,4-diamine, N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, N2-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, [4-Amino-6-[4-(3-methoxy-phenyl)-piperazin-1-ylmethyl]-1H-[1,3,5]triazin-2-ylidene]-(3,4-dimethyl-phenyl)-amine

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About This Item

Fórmula empírica (Notação de Hill):
C23H29N7O
Número CAS:
701224-63-7
Peso molecular:
419.52
Código UNSPSC:
12352107
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

2-8°C

Ações bioquímicas/fisiológicas

GLX481304 is a cell-permeable, noncytotoxic triazine-diamino compound that acts a potent, dual NOX2 and NOX4 isoform-selective inhibitor (IC50 ~ 1.25 μM) over NOX1. Does neither function as an antioxidant nor as a scavenger of reactive oxygen species (ROS). GLX481304 is shown to dose-dependently reduce ROS levels in hypoxia challenged mouse cardiomyocytes and improve contractile function in whole heart.
cell-permeable, noncytotoxic triazine-diamino compound that acts a potent, dual NOX2 and NOX4 isoform-selective inhibitor

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Ferenc L M Szekeres et al.
Scientific reports, 11(1), 11970-11970 (2021-06-09)
The NADPH oxidase enzymes Nox2 and 4, are important generators of Reactive oxygen species (ROS). These enzymes are abundantly expressed in cardiomyocytes and have been implicated in ischemia-reperfusion injury. Previous attempts with full inhibition of their activity using genetically modified
Isabel Cordero-Herrera et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(1), 217-226 (2018-12-19)
Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications

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