SML1527

Abiraterone acetate

≥98% (HPLC)

• Sinônimo(s): CB 7598, 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
• Fórmula empírica (Notação de Hill): C₂₆H₃₃NO₂
• Número CAS: 154229-18-2
• Peso molecular: 391.55
• Número MDL: MFCD00934213
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825944
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 5 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
• chave InChI: UVIQSJCZCSLXRZ-UBUQANBQSA-N
• Informações sobre genes: human ... CYP17A1(1586)

Descrição

Aplicação

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.

Ações bioquímicas/fisiológicas

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

Informações de segurança

• Pictogramas: GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H360F,H373,H410
• Declarações de precaução: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Classificações de perigo: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• Órgãos-alvo: Endocrine system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable