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M1323

Sigma-Aldrich

Midostaurin hydrate

≥98% (HPLC), solid, kinase inhibitor

Sinônimo(s):

CGP 41251, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide, N-benzoylstaurosporine, PKC-412

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About This Item

Fórmula empírica (Notação de Hill):
C35H30N4O4 · xH2O
Número CAS:
1217450-80-0
Peso molecular:
570.64 (anhydrous basis)
Número MDL:
MFCD12828879
Código UNSPSC:
12352200
ID de substância PubChem:
329817870
NACRES:
NA.77

Nome do produto

Midostaurin hydrate, ≥98% (HPLC), solid

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

cor

off-white

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9

InChI

1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1

chave InChI

YEKDLUZCCDJYAJ-LJAYRLSQSA-N

Ações bioquímicas/fisiológicas

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF.
Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

Características e benefícios

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H360FD

Classificações de perigo

Repr. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
026M4751V
056M4717V
075M4736V
065M4735V
103M4724V

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