SML1463

NHI-2

≥98% (HPLC)

• Sinônimo(s): 1-Hydroxy-6-phenyl-4-(trifluoromethyl)-1H-Indole-2-carboxylic acid methyl ester, Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
• Fórmula empírica (Notação de Hill): C₁₇H₁₂F₃NO₃
• Número CAS: 1269802-97-2
• Peso molecular: 335.28
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825897
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 20 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: ON(C(C(OC)=O)=C1)C2=C1C(C(F)(F)F)=CC(C3=CC=CC=C3)=C2
• InChI: 1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3
• chave InChI: YPPFWRWCZNXINO-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). NHI-2 has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells.

NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA).

NHI-2 possesses highr cell permeability.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable