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SML0847

Sigma-Aldrich

Benztropine mesylate

≥98% (HPLC)

Sinônimo(s):

Benzatropine mesylate, Benzotropine mesylate, Benztropine methanesulfonate

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About This Item

Fórmula empírica (Notação de Hill):
C21H25NO · CH3SO3H
Número CAS:
132-17-2
Peso molecular:
403.53
Número CE:
205-048-8
Número MDL:
MFCD00074784
Código UNSPSC:
12352200
ID de substância PubChem:
329825609
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

white to beige

solubilidade

H2O: 20 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4

InChI

1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;

chave InChI

CPFJLLXFNPCTDW-BWSPSPBFSA-N

Informações sobre genes

human ... CHRM1(1128)

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.

Aplicação

Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection. It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).

Ações bioquímicas/fisiológicas

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.
Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H302,H311 + H331

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate
Cui J, et al.
Oncotarget, 8(1), 1007-1007 (2017)
Target identification and mode of action of four chemically divergent drugs against ebolavirus infection
Ren J, et al.
Journal of medicinal chemistry, 61(3), 724-733 (2018)
Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)?A Potential Target to Treat Metabolic Disorders
Javed K, et al.
Clinical Therapeutics, 19(11), 3597-3597 (2018)
Björn Neumann et al.
Cell stem cell, 25(4), 473-485 (2019-10-05)
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show that the differentiation potential of adult
Lisa M Johansen et al.
Science translational medicine, 7(290), 290ra89-290ra89 (2015-06-05)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential

Artigos

Biogenic Amine Transporters

These distinct transporters, NET, DAT and SERT, respectively, are of particular clinical interest because they are the molecular targets for many antidepressants as well as drugs of abuse, such as cocaine and the amphetamines.

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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