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Documentos Principais

SML0797

Sigma-Aldrich

Flibanserin

≥98% (HPLC)

Sinônimo(s):

1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one, BIMT 17, BIMT 17BS

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About This Item

Fórmula empírica (Notação de Hill):
C20H21F3N4O
Número CAS:
167933-07-5
Peso molecular:
390.40
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 10 mg/mL, clear

temperatura de armazenamento

2-8°C

InChI

1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)

chave InChI

CCIZQGRSEAHATK-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H315,H319,H335

Classificações de perigo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
036M4715V
035M4719V
124M4708V
014M4706V

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Visite a Biblioteca de Documentos

Min-Yong Low et al.
Journal of pharmaceutical and biomedical analysis, 57, 104-108 (2011-10-01)
A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated from the health supplement and its structure was elucidated using LC-DAD, LC-FTMS, NMR and
[When women complain about lacking libido. The problem with the desire].
Katharina Arnheim
MMW Fortschritte der Medizin, 152(34-35), 12-13 (2010-10-07)
Evan R Goldfischer et al.
The journal of sexual medicine, 8(11), 3160-3172 (2011-09-22)
Flibanserin is a 5-HT(1A) agonist/5-HT(2A) antagonist that has been shown to increase sexual desire and reduce distress in premenopausal women with Hypoactive Sexual Desire Disorder (HSDD). To assess the efficacy and safety of flibanserin over 24 weeks of double-blind treatment
Resurgence of interest in sexual dysfunction?
Mike G Wyllie
BJU international, 109(11), E36-E37 (2012-05-09)
Iñaki F Trocóniz et al.
Pharmaceutical research, 29(6), 1518-1529 (2012-01-06)
Flibanserin is being developed for treating hypoactive sexual desire disorder in women; the main side effect is sedation. The analysis objective was to relate flibanserin plasma concentrations with acute sedative effects using a population pharmacokinetic/pharmacodynamic (PK/PD) model. The population model
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