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SML0234

Sigma-Aldrich

Mitiglinide calcium

≥98% (HPLC)

Sinônimo(s):

(aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt, KAD 1229, Mitiglinide hemicalcium salt, S 21403, [2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt

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About This Item

Fórmula empírica (Notação de Hill):
C19H24NO3·0.5Ca
Número CAS:
145525-41-3
Peso molecular:
334.44
Número MDL:
MFCD09955408
Código UNSPSC:
12352200
ID de substância PubChem:
329825247
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Formulário

powder

atividade óptica

[α]/D +5 to +9° (c=1, MeOH)

condição de armazenamento

desiccated

cor

white to beige

solubilidade

DMSO: ≥10 mg/mL at warmed to 60 °C

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

O=C(C[C@H](Cc1ccccc1)C(=O)O[Ca]OC(=O)[C@H](CC(=O)N2C[C@H]3CCCC[C@H]3C2)Cc4ccccc4)N5C[C@H]6CCCC[C@H]6C5

InChI

1S/2C19H25NO3.Ca/c2*21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;/h2*1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);/q;;+2/p-2/t2*15-,16+,17-;/m00./s1

chave InChI

PMRVFZXOCRHXFE-FMEJWYFOSA-L

Ações bioquímicas/fisiológicas

Mitiglinide calcium is a highly selective KATP channel antagonist
Mitiglinide is a drug for the treatment of type 2 diabetes. It is a highly selective KATP channel antagonist Mitiglinide is a hypoglycemic agent that closes adenosine triphosphate (ATP)–sensitive potassium channels (KATP channel s) in the pancreatic β-islet cells.

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
023M4720V
012M4704V

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H Konya et al.
The Journal of international medical research, 37(6), 1904-1912 (2010-02-12)
This study investigated the effects of mitiglinide in 16 patients with type 2 diabetes mellitus treated with 30 mg/day mitiglinide, divided into three doses given just before each meal, for approximately 12 months. A 450 kcal meal tolerance test was
Jin Ah Jung et al.
Clinical drug investigation, 32(12), 799-804 (2012-10-27)
In the treatment of diabetes mellitus, combined drugs with different mechanisms of action can be effective when adequate glycaemic control is difficult with monotherapy. A fixed-dose combination (FDC) tablet of mitiglinide and metformin has been developed as a second-line treatment
L Jin et al.
Arzneimittel-Forschung, 62(1), 40-45 (2012-02-15)
A sensitive and specific method was developed and validated for the determination of mitiglinide in plasma using LC-MS/MS. The effect of gemfibrozil on the pharmacokinetics of orally administered mitiglinide in rats was investigated. The validated method in positive electrospray ionization
Hind Hadi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 895-896, 131-136 (2012-04-17)
A hollow fiber liquid phase microextraction (HF-LPME) in conjunction with reversed phase HPLC-UV method was developed for the extraction and determination of trace amounts of the antidiabetic drug, mitiglinide (MIT) in biological fluids. The drug was extracted from 10 mL
Haley M Phillippe et al.
The Annals of pharmacotherapy, 44(10), 1615-1623 (2010-09-16)
To review the pharmacology, pharmacokinetics, efficacy, and safety of mitiglinide, a rapid-acting insulin secretion-stimulating agent to determine its potential role in therapy for the treatment of type 2 diabetes mellitus. A MEDLINE search (1966-May 2010) was conducted for English-language, human
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