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SML0189

Indinavir sulfate salt hydrate

Name: Indinavir sulfate salt hydrate
Brand: SIGMA

≥98% (HPLC), powder, antiretroviral agent

Sinônimo(s):

2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate hydrate, Crixivan hydrate, L-735,524 hydrate, MK-639 hydrate

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About This Item

Fórmula empírica (Notação de Hill):

C₃₆H₄₇N₅O₄·H₂SO₄ · xH₂O

Peso molecular:

711.87 (anhydrous basis)

Código UNSPSC:

51111800

NACRES:

NA.77

product name

Indinavir sulfate salt hydrate, ≥98% (HPLC)

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

white to tan

solubilidade

H₂O: ≥15 mg/mL

originador

Merck & Co., Inc., Kenilworth, NJ, U.S.

temperatura de armazenamento

2-8°C

Aplicação

Indinavir sulfate salt hydrate may be used in HIV-related cell signaling studies.

Ações bioquímicas/fisiológicas

Indinavir sulfate is an antiviral HIV protease inhibitor.

Indinavir sulfate suppresses the replication of HIV and is an important component of antiretroviral therapy for initial treatment of HIV infection. It is known to cause renal and urologic toxicity.

Características e benefícios

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Renal disease associated with antiretroviral therapy in the treatment of HIV.

Ryan D Cooper et al.

Nephron. Clinical practice, 118(3), c262-c268 (2011-01-08)

The introduction of potent combination antiretroviral therapy (ART) in the treatment of HIV infection has permitted reliable control of disease progression and has markedly improved survival among people with HIV. As a result, health care providers and patients have shifted

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake.

Benjamin Seyer et al.

Journal of neurochemistry, 153(4), 485-494 (2019-09-27)

Ethyl2-acetylamino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate (HFI-419), the benzopyran-based inhibitor of insulin-regulated aminopeptidase (IRAP), has previously been shown to improve spatial working and recognition memory in rodents. However, the mechanism of its cognitive-enhancing effect remains unknown. There is a close correlation between dendritic spine density

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