SMB00400

Ligustilide

≥96% (HPLC)

• Sinônimo(s): 3-butylidene-4,5-dihydro-1(3H)-isobenzofuranone, 3-butylidene-4,5-dihydrophthalide
• Fórmula empírica (Notação de Hill): C₁₂H₁₄O₂
• Número CAS: 4431-01-0
• Peso molecular: 190.24
• Número MDL: MFCD01861511
• Código UNSPSC: 12352205
• ID de substância PubChem: 329824991
• NACRES: NA.25

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥96% (HPLC)
• Formulário: liquid
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(O/C1=C\CCC)C2=C1CCC=C2
• InChI: 1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3/b11-8-
• chave InChI: IQVQXVFMNOFTMU-FLIBITNWSA-N

Descrição

Descrição geral

Ligustilide is a phthalide derivative and is one of the main lipophilic compounds of Danggui essential oil and Rhizoma Chuanxiong, a Chinese medicinal herb.

Aplicação

Ligustilide has been used as a treatment to test its anti-apoptotic effects on rat chondrocytes and sodium nitroprusside (SNP)-stimulated chondrocytes in both in vitro and in vivo studies. It has also been used as a treatment to study anti-atherosclerosis effects on high-fat diet-fed mice and cytoprotective effects on tert-butyl hydroperoxide (t-BHP)-evoked EA.hy926 cells.

Ações bioquímicas/fisiológicas

Ligustilide can inhibit the proliferation of and cell cycle progression of vascular smooth muscle cells and inhibits vasoconstriction. It increases vasodilation, anti-thrombosis, and serotonergic activity and decreases platelet aggregation. It has been shown to have broad applications in the study and treatment of cardiovascular diseases and ischemic brain injury. Ligustilide has the ability to reduce neurogenic and inflammatory pain. Thus, it can be used as a potential therapeutic agent to treat several pain syndromes including primary dysmenorrhoea.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable