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SBR00068

Sigma-Aldrich

Streptomycin Ready Made Solution

100 mg/mL in water

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About This Item

Número CAS:

forma

liquid

Nível de qualidade

atividade específica

(Antibacterial)

concentração

100 mg/mL in water

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

−20°C

Descrição geral

Chemical structure: aminoglycoside

Aplicação

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Ações bioquímicas/fisiológicas

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Armazenamento e estabilidade

  • Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
  • Streptomycin: sulfate salt ratio is 1:1.5.
  • The product is packed under aseptic conditions.

Pictogramas

Health hazard

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Repr. 2

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3


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