SAB5702238

Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal

• Sinônimo(s): B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274
• Código UNSPSC: 12352203
• NACRES: NA.46

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• Materiais: colorless
• clone: 8F1V6, monoclonal
• Formulário: liquid
• reatividade de espécies: human
• concentração: 0.65 mg/mL
• técnica(s): flow cytometry: 1:50 - 1:200
• cor: colorless
• Isotipo: IgG
• nº de adesão UniProt: Q9NZQ7
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PD-L1(29126)

Descrição

Descrição geral

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

Imunogênio

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human PD-L1/CD274.

Aplicação

ELISA, WB, FC, Inhibition

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1