SAB5701115

Anti-PD-L1/CD274 antibody produced in mouse

• Código UNSPSC: 12352203
• NACRES: NA.43

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: monoclonal
• Formulário: liquid
• reatividade de espécies: rat, mouse, monkey, human
• concentração: 1.51 mg/mL
• técnica(s): immunohistochemistry: 1:50-1:100; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• nº de adesão UniProt: Q9NZQ7
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PD-L1(29126)

Descrição

Descrição geral

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Imunogênio

Recombinant protein of human PD‐L1 extracellular domain.

forma física

Tris Buffer, pH7.3-7.7, with 1% BSA and <0.1% Sodium azide.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable