SAB4501318
Anti-MGLUR2 antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
GPRC1C, GRM3, MGR3, Metabotropic glutamate receptor 3 precursor, glutamate receptor
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 95 kDa
reatividade de espécies
rat, human, mouse
concentração
~1 mg/mL
técnica(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... GRM2(2912)
Descrição geral
Metabotropic glutamate receptor 2 (MGLUR2) with 872 amino acid residues is encoded by the gene mapped to human chromosome 3. MGLUR2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. MGLUR2 is characterized with an α-helical helix 8 (H8) domain.
Imunogênio
The antiserum was produced against synthesized peptide derived from human mGluR2/3.
Immunogen Range: 823-872
Immunogen Range: 823-872
Ações bioquímicas/fisiológicas
Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. MGLUR2 signaling inhibits adenylyl cyclase (AC) activity. MGLUR2 is crucial in the modulation of synaptic transmission.
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
H Ohishi et al.
Neuroscience, 53(4), 1009-1018 (1993-04-01)
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, which is coupled to the inhibitory cyclic AMP cascade, was investigated in the central nervous system of the adult rat by in situ hybridization. Transcripts of mGluR2 were specifically
Steve Davidson et al.
Pain, 157(9), 2081-2088 (2016-05-25)
We introduce a strategy for preclinical research wherein promising targets for analgesia are tested in rodent and subsequently validated in human sensory neurons. We evaluate group II metabotropic glutamate receptors, the activation of which is efficacious in rodent models of
Agostino Bruno et al.
PloS one, 7(8), e42023-e42023 (2012-08-08)
The recent elucidation of the X-ray structure of several class A GPCRs clearly indicates that the amphipathic helix 8 (H8) is a conserved structural domain in most crystallized GPCRs. Very little is known about the presence and the possible role
Driss El Moustaine et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16342-16347 (2012-09-19)
The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic transmission and are considered promising targets for the treatment of various brain disorders. Whereas glutamate acts at a large extracellular domain, allosteric modulators have been identified that bind to
A Farinha et al.
British journal of pharmacology, 172(9), 2383-2396 (2015-01-13)
The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these
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