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Documentos Principais

SAB4500455

Sigma-Aldrich

Anti-CBP antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

CREB-binding protein, CREBBP

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

antigen 265 kDa

reatividade de espécies

human, rat, mouse

concentração

~1 mg/mL

técnica(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CREBBP(1387)

Descrição geral

Anti-CBP Antibody detects endogenous levels of total CBP protein. CREB binding protein (CBP) is a histone acetyltransferase, which is part of the KAT3 family of histone acetyltransferases. The gene encoding it is localized on human chromosome 16p13.3.

Imunogênio

The antiserum was produced against synthesized peptide derived from human CBP.

Immunogen Range: 1501-1550

Ações bioquímicas/fisiológicas

CREB binding protein (CBP) has a role in the activation of the innate immune response, activation of histones and non-histones through acetylation. It also plays an important role in cAMP-dependent and Wnt signaling. The protein is also involved in modulating the cell cycle, DNA damage repair, ubiquitination and antigen presentation. Mutations in the CBP gene have been associated with Rubinstein-Taybi syndrome. It has also been linked with acute lymphoblastic leukemia.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.
Dixon ZA
Haematologica (2017)
Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP.
Protein Science (2016)
Submicroscopic deletions at 16p13.3 in
Rubinstein-Taybi syndrome: frequency and
clinical manifestations in a North American
population
Robert Wallerstein
Journal of medical Genetics (1997)
Jin Ran Chen et al.
The Journal of endocrinology (2018-07-28)
Intrauterine or early postnatal high-fat diet (HFD) have substantial influences on adult offspring health; however, studies of HFD-induced maternal obesity on regulation of adult offspring bone formation are sparse. Here, we investigated the effects of HFD-induced maternal obesity on both
Yujie Liu et al.
Molecular and cellular biology, 34(21), 3993-4007 (2014-08-27)
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. A histone/protein acetyltransferase (HAT), p300, was recently found to be important for Treg function and stability, but further insights into the mechanisms

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