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Key Documents

SAB4301137

Sigma-Aldrich

Anti-ACTIN antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

ACTB

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

42 kDa

reatividade de espécies

plant

concentração

1 mg/mL

técnica(s)

western blot: 1:500-1:2000 (Cell Lysate)

Isotipo

IgG

nº de adesão

NP_190236.1

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

Arabidopsis thaliana ... ACT12(823805)

Descrição geral

Actin/ actin β(ACTB) is encoded by the gene mapped to human chromosome 7p15-p12. In mammals, actin protein consists of six different isoforms encoded by separate genes. The four isoforms αskeletal-actin, αcardiac-actin, αsmooth-actin, and γ smooth-actin are expressed in skeletal, cardiac and smooth muscle. The other two isoforms, β cyto-actin and γ cyto-actin are ubiquitously expressed.

Especificidade

The antibody detects endogenous levels of total ACTIN protein.

Imunogênio

Synthetic peptide corresponding to residues near the N terminal of Arabidopsis thaliana actin

Ações bioquímicas/fisiológicas

Actin plays a vital role in various cellular processes, such as cell division, migration, junction formation, chromatin remodeling, transcriptional regulation, vesicle trafficking, and cell shape regulation. Polymorphism in the smooth muscle α-actin (ACTA2) is associated with the development of thoracic aortic aneurysms and dissections.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1


Certificados de análise (COA)

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Sublocalization of an invasion-inducing locus and other genes on human chromosome 7.
Habets G G M, et al.
Cytogenetic and genome research, 60(3-4), 200-205 (1992)
Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
Guo D C, et al.
Nature Genetics, 39(12), 1488-1488 (2007)
Bo Zeng et al.
Nature communications, 8(1), 1920-1920 (2017-12-06)
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN.
Dong Meng et al.
The Plant journal : for cell and molecular biology, 106(5), 1278-1297 (2021-03-19)
Calcineurin B-like (CBL)-interacting protein kinases (CIPKs) play a central role in Ca2+ signalling and promote drought tolerance in plants. The CIPK gene family in pigeon pea (Cajanus cajan L.), a major food crop affected by drought, has not previously been
Chuan-Jin Wu et al.
The Journal of clinical investigation, 127(2), 623-634 (2017-01-18)
Congenital tufting enteropathy (CTE) is a severe autosomal recessive human diarrheal disorder with characteristic intestinal epithelial dysplasia. CTE can be caused by mutations in genes encoding EpCAM, a putative adhesion molecule, and HAI-2, a cell surface protease inhibitor. A similar

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